Testin (Q9UGI8)

Uniprot ID Q9UGI8
Protein Name Testin
Gene Name TES
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.532
Function Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. .
GO - Molecular function
  • cadherin binding : HDA:BHF-UCL
  • RNA binding : HDA:UniProtKB
  • zinc ion binding : IDA:UniProtKB
GO - Biological process
  • negative regulation of cell proliferation : IMP:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.