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Q9R1Q9

V-type proton ATPase subunit S1 (Q9R1Q9)

Uniprot ID Q9R1Q9
Protein Name V-type proton ATPase subunit S1
Gene Name Atp6ap1
Species Mus musculus (Mouse)
Basic Information Experiments (3) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.667
Function Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • proton-transporting ATP synthase activity, rotational mechanism : IEA:InterPro
  • proton-transporting ATPase activity, rotational mechanism : IEA:InterPro
  • Rab GTPase binding : IPI:UniProtKB
GO - Biological process
  • ATP hydrolysis coupled proton transport : IEA:InterPro
  • cell death : ISO:MGI
  • cellular iron ion homeostasis : ISS:UniProtKB
  • cellular response to increased oxygen levels : ISS:UniProtKB
  • establishment of organelle localization : IMP:UniProtKB
  • pH reduction : IMP:UniProtKB
  • positive regulation of bone resorption : IMP:UniProtKB
  • positive regulation of ERK1 and ERK2 cascade : IMP:UniProtKB
  • positive regulation of exocytosis : IMP:UniProtKB
  • positive regulation of osteoblast differentiation : IMP:UniProtKB
  • positive regulation of osteoclast development : IMP:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.