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Q9R0S3

Matrix metalloproteinase-17 (Q9R0S3)

Uniprot ID Q9R0S3
Protein Name Matrix metalloproteinase-17
Gene Name Mmp17
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.609
Function Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin. .
GO - Molecular function
  • metalloendopeptidase activity : IEA:InterPro
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • drinking behavior : IMP:MGI
  • kidney development : IMP:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.