| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity). . |
| GO - Molecular function |
- cysteine-type endopeptidase activity : IMP:ARUK-UCL
- peptidase activity : ISO:RGD
|
| GO - Biological process |
- activation of cysteine-type endopeptidase activity : ISO:RGD
- associative learning : ISO:RGD
- cellular response to amyloid-beta : ISO:RGD
- cellular response to calcium ion : ISO:RGD
- cellular response to hepatocyte growth factor stimulus : ISO:RGD
- dendritic spine organization : ISO:RGD
- memory : ISO:RGD
- negative regulation of ERBB signaling pathway : ISS:UniProtKB
- negative regulation of gene expression : ISO:RGD
- negative regulation of multicellular organism growth : ISO:RGD
- negative regulation of neuron apoptotic process : ISO:RGD
- positive regulation of cell population proliferation : ISO:RGD
- positive regulation of endothelial cell chemotaxis : ISO:RGD
- positive regulation of long-term synaptic potentiation : ISO:RGD
- positive regulation of mitotic cell cycle : ISO:RGD
- positive regulation of monocyte chemotaxis : ISO:RGD
- proteolysis : ISS:UniProtKB
- proteolysis involved in cellular protein catabolic process : ISS:UniProtKB
- receptor catabolic process : ISS:UniProtKB
- renal system process : ISS:UniProtKB
- response to acidic pH : ISO:RGD
- self proteolysis : ISO:RGD
- vacuolar protein processing : IBA:GO_Central
|