Core histone macro-H2A.1 (Q9QZQ8)

Uniprot ID	Q9QZQ8
Protein Name	Core histone macro-H2A.1
Gene Name	H2afy
Species	Mus musculus (Mouse)

Signal peptide^(a)	N	Secretome P^(b)	0.454
Function	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (By similarity). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (By similarity) (PubMed:16107708). .Isoform 1: Binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation (By similarity). Increases the expression of genes involved in redox metabolism, including SOD3 (PubMed:23022728). {ECO:0000250\|UniProtKB:O75367, ECO:0000269\|PubMed:23022728}.Isoform 2: Represses SOD3 gene expression. {ECO:0000269\|PubMed:23022728}.
GO - Molecular function	chromatin binding : IDA:MGI chromatin DNA binding : ISO:MGI core promoter sequence-specific DNA binding : IDA:UniProtKB double-stranded methylated DNA binding : ISO:MGI enzyme binding : ISO:MGI nucleosomal DNA binding : IDA:UniProtKB protein heterodimerization activity : IEA:InterPro protein kinase binding : ISO:MGI protein serine/threonine kinase inhibitor activity : ISO:MGI rDNA binding : ISO:MGI RNA polymerase II core promoter sequence-specific DNA binding : ISO:MGI RNA polymerase II regulatory region sequence-specific DNA binding : ISO:MGI transcription regulatory region DNA binding : ISO:MGI
GO - Biological process	chromatin silencing : IBA:GO_Central dosage compensation : ISO:MGI establishment of protein localization to chromatin : ISO:MGI negative regulation of cell cycle G2/M phase transition : ISO:MGI negative regulation of gene expression, epigenetic : ISO:MGI negative regulation of histone H3-K27 methylation : ISO:MGI negative regulation of histone H3-K4 methylation : ISO:MGI negative regulation of histone phosphorylation : ISO:MGI negative regulation of protein localization to chromosome, telomeric region : ISO:MGI negative regulation of protein serine/threonine kinase activity : ISO:MGI negative regulation of response to oxidative stress : IMP:UniProtKB negative regulation of transcription by RNA polymerase II : ISO:MGI negative regulation of transcription of nucleolar large rRNA by RNA polymerase I : IMP:UniProtKB nucleosome assembly : IEA:InterPro positive regulation of gene expression, epigenetic : ISO:MGI positive regulation of keratinocyte differentiation : ISO:MGI positive regulation of maintenance of mitotic sister chromatid cohesion : ISO:MGI positive regulation of response to oxidative stress : IMP:UniProtKB regulation of gene expression, epigenetic : ISO:MGI regulation of histone methylation : IBA:GO_Central regulation of lipid metabolic process : IDA:MGI regulation of response to oxidative stress : IMP:UniProtKB

Back

^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}