| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells (By similarity). . |
| GO - Molecular function |
- deoxyribonuclease II activity : IBA:GO_Central
- endodeoxyribonuclease activity : IDA:RGD
|
| GO - Biological process |
- apoptotic DNA fragmentation : IBA:GO_Central
- erythrocyte differentiation : IEA:Ensembl
- regulation of immune response : IEA:Ensembl
|