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Q9QZ73

DCN1-like protein 1 (Q9QZ73)

Uniprot ID Q9QZ73
Protein Name DCN1-like protein 1
Gene Name Dcun1d1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.738
Function Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (By similarity). Acts also as an oncogene facilitating malignant transformation and carcinogenic in vivo (PubMed:20563250). .
GO - Molecular function
  • cullin family protein binding : IBA:GO_Central
  • ubiquitin conjugating enzyme binding : IBA:GO_Central
  • ubiquitin-like protein binding : IBA:GO_Central
GO - Biological process
  • positive regulation of protein neddylation : ISS:UniProtKB
  • positive regulation of ubiquitin-protein transferase activity : IBA:GO_Central
  • protein neddylation : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.