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Q9QYR9

Acyl-coenzyme A thioesterase 2, mitochondrial (Q9QYR9)

Uniprot ID Q9QYR9
Protein Name Acyl-coenzyme A thioesterase 2, mitochondrial
Gene Name Acot2
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.505
Function Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Most active on substrates with chain lengths ranging from C14-C20. The enzyme is involved in enhancing the hepatic fatty acid oxidation in meitochondria. .
GO - Molecular function
  • acyl-CoA hydrolase activity : ISO:MGI
  • carboxylic ester hydrolase activity : IEA:UniProtKB-KW
  • myristoyl-CoA hydrolase activity : IEA:UniProtKB-EC
  • palmitoyl-CoA hydrolase activity : ISO:MGI
  • signaling receptor binding : ISO:MGI
GO - Biological process
  • acyl-CoA metabolic process : ISO:MGI
  • fatty acid metabolic process : IBA:GO_Central
  • long-chain fatty acid metabolic process : ISO:MGI
  • response to hypoxia : ISO:MGI
  • very long-chain fatty acid catabolic process : ISO:MGI
  • very long-chain fatty acid metabolic process : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.