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Q9QYH6

Melanoma-associated antigen D1 (Q9QYH6)

Uniprot ID Q9QYH6
Protein Name Melanoma-associated antigen D1
Gene Name Maged1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) N Secretome P(b) 0.256
Function Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA coregulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. .
GO - Molecular function
  • identical protein binding : ISO:MGI
  • transcription coactivator activity : IDA:MGI
GO - Biological process
  • circadian regulation of gene expression : IMP:UniProtKB
  • negative regulation of epithelial cell proliferation : ISO:MGI
  • negative regulation of transcription, DNA-templated : IMP:UniProtKB
  • positive regulation of apoptotic signaling pathway : IMP:MGI
  • positive regulation of branching involved in ureteric bud morphogenesis : IMP:UniProtKB
  • positive regulation of MAP kinase activity : IMP:UniProtKB
  • positive regulation of transcription, DNA-templated : IMP:UniProtKB
  • regulation of circadian rhythm : IMP:UniProtKB
  • regulation of transcription by RNA polymerase II : IDA:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.