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Q9QY93

dCTP pyrophosphatase 1 (Q9QY93)

Uniprot ID Q9QY93
Protein Name dCTP pyrophosphatase 1
Gene Name Dctpp1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.844
Function Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. .
GO - Molecular function
  • dCTP diphosphatase activity : ISO:MGI
  • identical protein binding : ISO:MGI
  • magnesium ion binding : IDA:UniProtKB
  • nucleoside-triphosphate diphosphatase activity : IDA:UniProtKB
  • pyrimidine deoxyribonucleotide binding : IDA:MGI
  • pyrophosphatase activity : IDA:MGI
GO - Biological process
  • dCTP catabolic process : ISO:MGI
  • DNA protection : ISS:UniProtKB
  • nucleoside triphosphate catabolic process : IDA:UniProtKB
  • protein homotetramerization : IDA:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.