| Signal peptide(a) |
Y |
Secretome P(b) |
0.281 |
| Function |
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). May regulate fibroblast growth factor-induced angiogenesis. . |
| GO - Molecular function |
- calcium ion binding : NAS:UniProtKB
- Notch binding : IPI:UniProtKB
- phospholipid binding : ISO:MGI
- receptor ligand activity : ISO:MGI
|
| GO - Biological process |
- animal organ morphogenesis : IMP:MGI
- aorta morphogenesis : IMP:BHF-UCL
- blood vessel remodeling : IMP:MGI
- camera-type eye development : IMP:MGI
- cardiac neural crest cell development involved in outflow tract morphogenesis : IMP:BHF-UCL
- cardiac right ventricle morphogenesis : IMP:BHF-UCL
- cardiac septum morphogenesis : IMP:BHF-UCL
- ciliary body morphogenesis : IMP:MGI
- distal tubule development : IEP:UniProtKB
- endocardial cushion cell development : IMP:BHF-UCL
- glomerular visceral epithelial cell development : IMP:UniProtKB
- inner ear auditory receptor cell differentiation : IMP:MGI
- inner ear development : IMP:UniProtKB
- loop of Henle development : IEP:UniProtKB
- morphogenesis of an epithelial sheet : IMP:MGI
- negative regulation of cell differentiation : IMP:MGI
- negative regulation of cell migration : ISO:MGI
- negative regulation of cell-cell adhesion : ISO:MGI
- negative regulation of cell-matrix adhesion : ISO:MGI
- negative regulation of endothelial cell differentiation : IDA:BHF-UCL
- negative regulation of fat cell differentiation : IDA:MGI
- negative regulation of neuron differentiation : IMP:MGI
- negative regulation of stem cell differentiation : ISO:MGI
- nephron development : IMP:UniProtKB
- neuronal stem cell population maintenance : IEA:Ensembl
- Notch signaling involved in heart development : IMP:BHF-UCL
- Notch signaling pathway : IDA:MGI
- positive regulation of myeloid cell differentiation : IDA:MGI
- positive regulation of Notch signaling pathway : IDA:UniProtKB
- positive regulation of osteoblast differentiation : IDA:MGI
- positive regulation of transcription by RNA polymerase II : IMP:BHF-UCL
- pulmonary artery morphogenesis : ISS:BHF-UCL
- pulmonary valve morphogenesis : ISS:BHF-UCL
- regulation of cell proliferation : IGI:MGI
- response to muramyl dipeptide : IDA:BHF-UCL
- T cell mediated immunity : ISO:MGI
|