Signal peptide(a) |
N |
Secretome P(b) |
0.0 |
Function |
Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation (By similarity). . |
GO - Molecular function |
- GDP-dissociation inhibitor activity : IEA:InterPro
- GTPase activator activity : IEA:UniProtKB-KW
- protein-containing complex binding : ISO:MGI
- Rab GTPase binding : ISS:UniProtKB
|
GO - Biological process |
- blood vessel development : IMP:MGI
- protein geranylgeranylation : ISS:UniProtKB
- protein targeting to membrane : ISS:UniProtKB
- protein-containing complex assembly : ISO:MGI
- small GTPase mediated signal transduction : IEA:InterPro
- vesicle-mediated transport : IBA:GO_Central
|