Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
Q9QWF0

Chromatin assembly factor 1 subunit A (Q9QWF0)

Uniprot ID Q9QWF0
Protein Name Chromatin assembly factor 1 subunit A
Gene Name Chaf1a
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.236
Function Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. .
GO - Molecular function
  • chromo shadow domain binding : ISO:MGI
  • identical protein binding : ISO:MGI
GO - Biological process
  • cell cycle : IEA:UniProtKB-KW
  • chromatin assembly : ISS:UniProtKB
  • DNA repair : IEA:UniProtKB-KW
  • DNA replication : IEA:UniProtKB-KW
  • DNA replication-dependent nucleosome assembly : ISO:MGI
  • nucleosome assembly : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.