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Q9QUR8

Semaphorin-7A (Q9QUR8)

Uniprot ID Q9QUR8
Protein Name Semaphorin-7A
Gene Name Sema7a
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.486
Function Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. .
GO - Molecular function
  • integrin binding : IPI:UniProtKB
  • neuropilin binding : IBA:GO_Central
GO - Biological process
  • axon extension : IDA:MGI
  • inflammatory response : IEA:UniProtKB-KW
  • integrin-mediated signaling pathway : IDA:UniProtKB
  • negative chemotaxis : IBA:GO_Central
  • neuron projection development : IMP:MGI
  • olfactory lobe development : IDA:MGI
  • positive regulation of axon extension : IDA:MGI
  • positive regulation of ERK1 and ERK2 cascade : IDA:UniProtKB
  • positive regulation of macrophage cytokine production : IDA:UniProtKB
  • positive regulation of protein phosphorylation : IDA:MGI
  • regulation of inflammatory response : IDA:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.