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Q9NY97

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (Q9NY97)

Uniprot ID Q9NY97
Protein Name N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
Gene Name B3GNT2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.631
Function Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. .
GO - Molecular function
  • acetylgalactosaminyltransferase activity : IBA:GO_Central
  • acetylglucosaminyltransferase activity : IBA:GO_Central
  • beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity : IEA:UniProtKB-EC
  • galactosyltransferase activity : IEA:InterPro
  • N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity : IDA:UniProtKB
  • transferase activity, transferring hexosyl groups : IBA:GO_Central
GO - Biological process
  • axon guidance : IEA:Ensembl
  • cellular response to leukemia inhibitory factor : IEA:Ensembl
  • keratan sulfate biosynthetic process : TAS:Reactome
  • O-glycan processing : TAS:Reactome
  • poly-N-acetyllactosamine biosynthetic process : IDA:UniProtKB
  • protein glycosylation : IBA:GO_Central
  • protein O-linked glycosylation : IBA:GO_Central
  • sensory perception of smell : IEA:Ensembl
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.