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Q9NR45

Sialic acid synthase (Q9NR45)

Uniprot ID Q9NR45
Protein Name Sialic acid synthase
Gene Name NANS
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.727
Function Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.
GO - Molecular function
  • N-acetylneuraminate synthase activity : IEA:UniProtKB-EC
  • N-acylneuraminate cytidylyltransferase activity : NAS:UniProtKB
  • N-acylneuraminate-9-phosphate synthase activity : TAS:Reactome
GO - Biological process
  • carbohydrate biosynthetic process : IEA:InterPro
  • CMP-N-acetylneuraminate biosynthetic process : NAS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.