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Q9NPF4

Probable tRNA N6-adenosine threonylcarbamoyltransferase (Q9NPF4)

Uniprot ID Q9NPF4
Protein Name Probable tRNA N6-adenosine threonylcarbamoyltransferase
Gene Name OSGEP
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.786
Function Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. .
GO - Molecular function
  • metal ion binding : IEA:UniProtKB-KW
  • N(6)-L-threonylcarbamoyladenine synthase activity : IEA:UniProtKB-EC
GO - Biological process
  • tRNA threonylcarbamoyladenosine modification : IDA:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.