| Signal peptide(a) |
N |
Secretome P(b) |
0.809 |
| Function |
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. |
| GO - Molecular function |
- chondroitin 4-sulfotransferase activity : IDA:UniProtKB
- N-acetylgalactosamine 4-O-sulfotransferase activity : IDA:UniProtKB
- N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity : IEA:Ensembl
- sulfotransferase activity : IBA:GO_Central
|
| GO - Biological process |
- carbohydrate biosynthetic process : IEA:InterPro
- chondrocyte development : IEA:Ensembl
- chondroitin sulfate biosynthetic process : IDA:UniProtKB
- developmental growth : IEA:Ensembl
- embryonic digit morphogenesis : IEA:Ensembl
- embryonic viscerocranium morphogenesis : IEA:Ensembl
- in utero embryonic development : IEA:Ensembl
- negative regulation of apoptotic process : IEA:Ensembl
- negative regulation of transforming growth factor beta receptor signaling pathway : IEA:Ensembl
- polysaccharide localization : IEA:Ensembl
- post-anal tail morphogenesis : IEA:Ensembl
- post-embryonic development : IEA:Ensembl
- proteoglycan biosynthetic process : IBA:GO_Central
- regulation of cell population proliferation : IEA:Ensembl
- respiratory gaseous exchange by respiratory system : IEA:Ensembl
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