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Q9NP84

Tumor necrosis factor receptor superfamily member 12A (Q9NP84)

Uniprot ID Q9NP84
Protein Name Tumor necrosis factor receptor superfamily member 12A
Gene Name TNFRSF12A
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.602
Function Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. .
GO - Molecular function
GO - Biological process
  • angiogenesis : IEA:UniProtKB-KW
  • extrinsic apoptotic signaling pathway : IEA:Ensembl
  • positive regulation of apoptotic process : IDA:UniProtKB
  • positive regulation of axon extension : IEA:Ensembl
  • positive regulation of extrinsic apoptotic signaling pathway : IMP:UniProtKB
  • regulation of angiogenesis : IEA:Ensembl
  • regulation of wound healing : IDA:UniProtKB
  • substrate-dependent cell migration, cell attachment to substrate : IEA:Ensembl
  • tumor necrosis factor-mediated signaling pathway : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.