| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress. May also play a role in the rupture of the nuclear envelope during apoptosis. May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1. . |
| GO - Molecular function |
- cyclin binding : ISO:RGD
- MDM2/MDM4 family protein binding : ISO:RGD
- mitogen-activated protein kinase binding : ISO:RGD
- NF-kappaB binding : ISO:RGD
- protein kinase binding : ISO:RGD
- protein-containing complex binding : IDA:RGD
- ubiquitin-like protein ligase binding : ISS:UniProtKB
|
| GO - Biological process |
- apoptotic nuclear changes : ISS:UniProtKB
- brain development : TAS:RGD
- cell population proliferation : ISS:UniProtKB
- endoplasmic reticulum unfolded protein response : ISS:UniProtKB
- mitotic G2 DNA damage checkpoint : ISS:UniProtKB
- mitotic G2/M transition checkpoint : ISS:UniProtKB
- negative regulation of cellular protein catabolic process : ISS:UniProtKB
- negative regulation of MAP kinase activity : ISS:UniProtKB
- negative regulation of NF-kappaB transcription factor activity : ISS:UniProtKB
- negative regulation of protein kinase activity by regulation of protein phosphorylation : ISS:UniProtKB
- negative regulation of protein phosphorylation : ISS:UniProtKB
- negative regulation of protein serine/threonine kinase activity : ISS:UniProtKB
- positive regulation of protein localization to nucleus : ISS:UniProtKB
- positive regulation of protein ubiquitination : ISS:UniProtKB
- positive regulation of signal transduction by p53 class mediator : ISS:UniProtKB
- positive regulation of transcription by RNA polymerase II : ISO:RGD
- protein ufmylation : ISO:RGD
- regulation of cyclin-dependent protein serine/threonine kinase activity : IDA:UniProtKB
- regulation of mitotic cell cycle : IBA:GO_Central
- regulation of neuron differentiation : TAS:RGD
- regulation of phosphatase activity : ISS:UniProtKB
|