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Q9JJV2

Profilin-2 (Q9JJV2)

Uniprot ID Q9JJV2
Protein Name Profilin-2
Gene Name Pfn2
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) N Secretome P(b) 0.903
Function Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
GO - Molecular function
  • actin binding : ISO:MGI
  • actin monomer binding : ISO:MGI
  • ATPase activity : ISO:MGI
  • phosphatidylinositol-4,5-bisphosphate binding : ISO:MGI
GO - Biological process
  • actin cytoskeleton organization : IEA:InterPro
  • negative regulation of actin filament polymerization : IDA:MGI
  • negative regulation of epithelial cell migration : IMP:UniProtKB
  • negative regulation of ruffle assembly : IMP:UniProtKB
  • positive regulation of actin filament bundle assembly : ISO:MGI
  • positive regulation of actin filament polymerization : IMP:MGI
  • positive regulation of ATPase activity : ISO:MGI
  • positive regulation of peptidyl-serine phosphorylation : IMP:UniProtKB
  • positive regulation of stress fiber assembly : IMP:UniProtKB
  • protein stabilization : ISO:MGI
  • regulation of synaptic vesicle exocytosis : IMP:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.