| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double-and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. . |
| GO - Molecular function |
- AT DNA binding : IDA:RGD
- chromatin binding : IDA:RGD
- histone deacetylase binding : IPI:RGD
- mRNA 3'-UTR AU-rich region binding : IDA:RGD
- mRNA binding : IDA:RGD
- RNA binding : ISS:UniProtKB
- sequence-specific DNA binding : IBA:GO_Central
- sequence-specific double-stranded DNA binding : IBA:GO_Central
- telomeric DNA binding : ISS:UniProtKB
- transcription factor binding : IPI:RGD
|
| GO - Biological process |
- 3'-UTR-mediated mRNA destabilization : IMP:RGD
- brain development : IEP:RGD
- cellular response to amino acid stimulus : IEP:RGD
- cellular response to estradiol stimulus : IEP:RGD
- cellular response to nitric oxide : IDA:RGD
- cellular response to putrescine : IDA:RGD
- cerebellum development : IEP:RGD
- circadian regulation of translation : ISS:UniProtKB
- hepatocyte dedifferentiation : IEP:RGD
- liver development : IEP:RGD
- mRNA stabilization : IDA:RGD
- mRNA transcription by RNA polymerase II : ISO:RGD
- negative regulation of gene expression : IMP:RGD
- nuclear-transcribed mRNA catabolic process, exonucleolytic : TAS:RGD
- nucleocytoplasmic transport : TAS:RGD
- positive regulation of gene expression : IMP:RGD
- positive regulation of telomerase RNA reverse transcriptase activity : ISO:RGD
- positive regulation of telomere capping : ISO:RGD
- positive regulation of translation : ISS:UniProtKB
- regulation of circadian rhythm : ISS:UniProtKB
- regulation of mRNA stability : ISO:RGD
- regulation of RNA metabolic process : IBA:GO_Central
- regulation of telomere maintenance : ISO:RGD
- response to calcium ion : IDA:RGD
- response to electrical stimulus : IEP:RGD
- response to estradiol : IEP:RGD
- response to rapamycin : IDA:RGD
- response to sodium phosphate : IDA:RGD
|