| Signal peptide(a) |
N |
Secretome P(b) |
0.881 |
| Function |
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. .May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation. {ECO:0000269|PubMed:12010804}. |
| GO - Molecular function |
- calcium ion binding : ISS:UniProtKB
- CD4 receptor binding : ISS:UniProtKB
- DNA binding : IEA:UniProtKB-KW
- enzyme binding : ISO:MGI
- epidermal growth factor receptor binding : ISS:UniProtKB
- phospholipid scramblase activity : ISS:UniProtKB
- SH3 domain binding : ISS:UniProtKB
- transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding : ISS:UniProtKB
|
| GO - Biological process |
- acute-phase response : IEP:UniProtKB
- apoptotic process : ISO:MGI
- cellular response to cytokine stimulus : IEP:UniProtKB
- cellular response to lipopolysaccharide : IEP:UniProtKB
- defense response to virus : IMP:UniProtKB
- immune response : ISO:MGI
- intrinsic apoptotic signaling pathway : IDA:UniProtKB
- myeloid cell differentiation : IMP:MGI
- negative regulation of protein binding : IDA:MGI
- negative regulation of viral genome replication : IMP:UniProtKB
- phosphatidylserine biosynthetic process : IDA:UniProtKB
- phosphatidylserine exposure on apoptotic cell surface : IDA:MGI
- phospholipid scrambling : IDA:UniProtKB
- positive regulation of apoptotic process : IGI:MGI
- positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity : ISS:UniProtKB
- positive regulation of gene expression : ISO:MGI
- positive regulation of innate immune response : IMP:UniProtKB
- positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage : IDA:MGI
- positive regulation of transcription by RNA polymerase II : ISS:UniProtKB
- regulation of Fc receptor mediated stimulatory signaling pathway : ISS:UniProtKB
- regulation of mast cell activation : ISS:UniProtKB
- response to interferon-alpha : IMP:UniProtKB
- response to interferon-beta : ISO:MGI
|