Syntenin-1 (Q9JI92)

Uniprot ID	Q9JI92
Protein Name	Syntenin-1
Gene Name	Sdcbp
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	N	Secretome P^(b)
Function	Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. .
GO - Molecular function	cell adhesion molecule binding : IPI:RGD ephrin receptor binding : IPI:RGD frizzled binding : ISO:RGD growth factor binding : IPI:RGD identical protein binding : IPI:RGD interleukin-5 receptor binding : ISS:UniProtKB neurexin family protein binding : IPI:RGD phosphatidylinositol-4,5-bisphosphate binding : ISO:RGD protein C-terminus binding : IPI:RGD protein heterodimerization activity : ISO:RGD protein N-terminus binding : ISO:RGD protein-containing complex binding : IPI:RGD syndecan binding : IPI:RGD
GO - Biological process	actin cytoskeleton organization : IEA:InterPro chemical synaptic transmission : IEA:InterPro negative regulation of proteasomal ubiquitin-dependent protein catabolic process : ISS:UniProtKB negative regulation of receptor internalization : ISS:UniProtKB positive regulation of cell growth : ISS:UniProtKB positive regulation of cell migration : ISS:UniProtKB positive regulation of cell population proliferation : ISS:UniProtKB positive regulation of epithelial to mesenchymal transition : ISS:UniProtKB positive regulation of exosomal secretion : ISO:RGD positive regulation of extracellular exosome assembly : ISO:RGD positive regulation of pathway-restricted SMAD protein phosphorylation : ISS:UniProtKB positive regulation of phosphorylation : ISO:RGD positive regulation of transforming growth factor beta receptor signaling pathway : ISS:UniProtKB presynapse assembly : IDA:SynGO Ras protein signal transduction : ISO:RGD regulation of mitotic cell cycle : ISS:UniProtKB

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}