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Q9H5N1

Rab GTPase-binding effector protein 2 (Q9H5N1)

Uniprot ID Q9H5N1
Protein Name Rab GTPase-binding effector protein 2
Gene Name RABEP2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.345
Function Plays a role in membrane trafficking and in homotypic early endosome fusion (PubMed:9524116). Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking (PubMed:29425100). By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis (PubMed:27224062). .
GO - Molecular function
  • growth factor activity : IEA:InterPro
  • GTPase activator activity : IEA:InterPro
GO - Biological process
  • cell projection organization : IEA:UniProtKB-KW
  • endocytosis : IEA:UniProtKB-KW
  • protein transport : IEA:UniProtKB-KW
  • regulation of cilium assembly : IMP:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.