| Signal peptide(a) |
Y |
Secretome P(b) |
0.236 |
| Function |
Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity). . |
| GO - Molecular function |
- chemorepellent activity : IBA:GO_Central
- semaphorin receptor binding : IBA:GO_Central
|
| GO - Biological process |
- animal organ morphogenesis : NAS:UniProtKB
- apoptotic process : NAS:UniProtKB
- axon guidance : NAS:UniProtKB
- cell surface receptor signaling pathway : NAS:UniProtKB
- cellular response to vascular endothelial growth factor stimulus : IDA:BHF-UCL
- cytoskeleton organization : NAS:UniProtKB
- negative chemotaxis : IBA:GO_Central
- negative regulation of angiogenesis : IGI:BHF-UCL
- negative regulation of axon extension involved in axon guidance : IBA:GO_Central
- negative regulation of cell adhesion involved in sprouting angiogenesis : IGI:BHF-UCL
- negative regulation of ERK1 and ERK2 cascade : IDA:BHF-UCL
- negative regulation of sprouting angiogenesis : IDA:BHF-UCL
- negative regulation of vascular endothelial growth factor signaling pathway : IDA:BHF-UCL
- nervous system development : NAS:UniProtKB
- neural crest cell migration : IBA:GO_Central
- positive regulation of cell migration : IBA:GO_Central
- positive regulation of neuron migration : IBA:GO_Central
- semaphorin-plexin signaling pathway : IBA:GO_Central
|