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Q9H013

Disintegrin and metalloproteinase domain-containing protein 19 (Q9H013)

Uniprot ID Q9H013
Protein Name Disintegrin and metalloproteinase domain-containing protein 19
Gene Name ADAM19
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.046
Function Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). .
GO - Molecular function
  • metal ion binding : IEA:UniProtKB-KW
  • metalloendopeptidase activity : IMP:UniProtKB
  • SH3 domain binding : IEA:UniProtKB-KW
GO - Biological process
  • extracellular matrix organization : TAS:Reactome
  • membrane protein ectodomain proteolysis : IEA:InterPro
  • placenta development : IEP:UniProtKB
  • positive regulation of cell-cell adhesion mediated by cadherin : IDA:UniProtKB
  • positive regulation of gene expression : IDA:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.