| Signal peptide(a) |
N |
Secretome P(b) |
0.776 |
| Function |
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). . |
| GO - Molecular function |
- transforming growth factor beta binding : IDA:BHF-UCL
|
| GO - Biological process |
- BMP signaling pathway : IEA:Ensembl
- camera-type eye development : IEA:Ensembl
- cell differentiation : IEA:Ensembl
- forebrain development : IEA:Ensembl
- hemopoiesis : IEA:Ensembl
- mesoderm formation : IEA:Ensembl
- negative regulation of BMP signaling pathway : IEA:Ensembl
- negative regulation of CD4-positive, alpha-beta T cell activation : IDA:BHF-UCL
- negative regulation of CD4-positive, alpha-beta T cell proliferation : IDA:BHF-UCL
- negative regulation of cytokine production : IDA:BHF-UCL
- negative regulation of osteoblast differentiation : IEA:Ensembl
- ossification : IEA:Ensembl
- positive regulation of BMP signaling pathway : IEA:Ensembl
- positive regulation of pathway-restricted SMAD protein phosphorylation : IDA:BHF-UCL
- regulation of BMP signaling pathway : IBA:GO_Central
- salivary gland morphogenesis : IEA:Ensembl
- transforming growth factor beta receptor signaling pathway : IDA:BHF-UCL
|