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Q9ESP7

A disintegrin and metalloproteinase with thrombospondin motifs 4 (Q9ESP7)

Uniprot ID Q9ESP7
Protein Name A disintegrin and metalloproteinase with thrombospondin motifs 4
Gene Name Adamts4
Species Rattus norvegicus (Rat)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.0
Function Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
GO - Molecular function
  • metal ion binding : IEA:UniProtKB-KW
  • metalloendopeptidase activity : ISO:RGD
  • metallopeptidase activity : ISO:RGD
  • protease binding : ISO:RGD
GO - Biological process
  • defense response to bacterium : ISO:RGD
  • proteolysis : ISO:RGD
  • tooth eruption : IEP:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.