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Q9EQV6

Tripeptidyl-peptidase 1 (Q9EQV6)

Uniprot ID Q9EQV6
Protein Name Tripeptidyl-peptidase 1
Gene Name Tpp1
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus. .
GO - Molecular function
  • endopeptidase activity : IDA:RGD
  • lysophosphatidic acid binding : ISS:UniProtKB
  • metal ion binding : IEA:UniProtKB-KW
  • peptidase activity : ISS:UniProtKB
  • peptide binding : IDA:RGD
  • serine-type endopeptidase activity : IEA:InterPro
  • serine-type peptidase activity : ISS:UniProtKB
  • sulfatide binding : ISS:UniProtKB
  • tripeptidyl-peptidase activity : IDA:RGD
GO - Biological process
  • bone resorption : ISS:UniProtKB
  • central nervous system development : IBA:GO_Central
  • epithelial cell differentiation : ISO:RGD
  • lysosome organization : ISO:RGD
  • nervous system development : ISS:UniProtKB
  • neuromuscular process controlling balance : ISO:RGD
  • peptide catabolic process : ISS:UniProtKB
  • proteolysis : IDA:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.