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Q9EQC1

3 beta-hydroxysteroid dehydrogenase type 7 (Q9EQC1)

Uniprot ID Q9EQC1
Protein Name 3 beta-hydroxysteroid dehydrogenase type 7
Gene Name Hsd3b7
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) N Secretome P(b) 0.488
Function The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (PubMed:22999953). .
GO - Molecular function
  • 3-beta-hydroxy-delta5-steroid dehydrogenase activity : IEA:InterPro
  • cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity : IMP:UniProtKB
GO - Biological process
  • B cell chemotaxis : IMP:UniProtKB
  • cholesterol catabolic process : ISO:MGI
  • regulation of cell growth : ISO:MGI
  • steroid biosynthetic process : IEA:UniProtKB-UniPathway
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.