| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability. . |
| GO - Molecular function |
- mRNA 3'-UTR binding : ISO:RGD
- mRNA binding : IDA:RGD
- poly(A) binding : ISS:UniProtKB
- poly(U) RNA binding : ISO:RGD
- protein C-terminus binding : ISO:RGD
- RNA binding : ISO:RGD
|
| GO - Biological process |
- gene silencing by RNA : ISS:UniProtKB
- mRNA processing : IEA:UniProtKB-KW
- negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay : ISS:UniProtKB
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay : IEA:UniProtKB-KW
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay : ISS:UniProtKB
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening : ISS:UniProtKB
- positive regulation of viral genome replication : ISO:RGD
- RNA splicing : IEA:UniProtKB-KW
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