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Q9C0C7

Activating molecule in BECN1-regulated autophagy protein 1 (Q9C0C7)

Uniprot ID Q9C0C7
Protein Name Activating molecule in BECN1-regulated autophagy protein 1
Gene Name AMBRA1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.392
Function Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity). .
GO - Molecular function
  • GTPase binding : IPI:UniProtKB
  • ubiquitin protein ligase binding : IPI:ParkinsonsUK-UCL
GO - Biological process
  • autophagosome assembly : IMP:ParkinsonsUK-UCL
  • autophagy : IBA:GO_Central
  • autophagy of mitochondrion : IGI:ParkinsonsUK-UCL
  • cell differentiation : IEA:UniProtKB-KW
  • cellular response to starvation : IEA:Ensembl
  • macroautophagy : TAS:Reactome
  • mitophagy : IDA:ParkinsonsUK-UCL
  • negative regulation of cardiac muscle cell apoptotic process : IEA:Ensembl
  • negative regulation of cell population proliferation : IEA:Ensembl
  • negative regulation of neuron apoptotic process : IEA:Ensembl
  • neural tube development : IEA:Ensembl
  • positive regulation of autophagy : IEA:Ensembl
  • positive regulation of phosphatidylinositol 3-kinase activity : IDA:ParkinsonsUK-UCL
  • response to mitochondrial depolarisation : IDA:ParkinsonsUK-UCL
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.