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Q9BY32

Inosine triphosphate pyrophosphatase (Q9BY32)

Uniprot ID Q9BY32
Protein Name Inosine triphosphate pyrophosphatase
Gene Name ITPA
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.904
Function Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy-and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. .
GO - Molecular function
  • dITP diphosphatase activity : EXP:Reactome
  • identical protein binding : IPI:IntAct
  • ITP diphosphatase activity : EXP:Reactome
  • metal ion binding : IEA:UniProtKB-KW
  • NADH pyrophosphatase activity : IEA:UniProtKB-EC
  • nucleoside-triphosphate diphosphatase activity : IBA:GO_Central
  • nucleotide binding : IEA:UniProtKB-KW
  • XTP diphosphatase activity : EXP:Reactome
GO - Biological process
  • chromosome organization : IEA:Ensembl
  • ITP catabolic process : IEA:Ensembl
  • nucleoside triphosphate catabolic process : IBA:GO_Central
  • purine nucleotide catabolic process : TAS:Reactome
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.