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Q9BU40

Chordin-like protein 1 (Q9BU40)

Uniprot ID Q9BU40
Protein Name Chordin-like protein 1
Gene Name CHRDL1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.698
Function Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. .
GO - Molecular function
GO - Biological process
  • BMP signaling pathway : TAS:Reactome
  • cell differentiation : IEA:UniProtKB-KW
  • cellular protein metabolic process : TAS:Reactome
  • compound eye development : IMP:UniProtKB
  • eye development : IMP:UniProtKB
  • negative regulation of BMP signaling pathway : IEA:Ensembl
  • nervous system development : IEA:UniProtKB-KW
  • ossification : IEA:UniProtKB-KW
  • post-translational protein modification : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.