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Q9BTT0

Acidic leucine-rich nuclear phosphoprotein 32 family member E (Q9BTT0)

Uniprot ID Q9BTT0
Protein Name Acidic leucine-rich nuclear phosphoprotein 32 family member E
Gene Name ANP32E
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.132
Function Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. .
GO - Molecular function
  • histone binding : IDA:UniProtKB
  • phosphatase inhibitor activity : ISS:UniProtKB
GO - Biological process
  • histone exchange : IDA:UniProtKB
  • nucleocytoplasmic transport : IBA:GO_Central
  • nucleosome assembly : IBA:GO_Central
  • regulation of apoptotic process : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.