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Q9BS26

Endoplasmic reticulum resident protein 44 (Q9BS26)

Uniprot ID Q9BS26
Protein Name Endoplasmic reticulum resident protein 44
Gene Name ERP44
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.415
Function Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum. .
GO - Molecular function
  • protein disulfide isomerase activity : IDA:UniProtKB
GO - Biological process
  • cell redox homeostasis : TAS:UniProtKB
  • glycoprotein metabolic process : IDA:UniProtKB
  • neutrophil degranulation : TAS:Reactome
  • protein folding : IDA:UniProtKB
  • response to endoplasmic reticulum stress : IDA:UniProtKB
  • response to unfolded protein : IDA:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.