Semaphorin-3C (Q99985)

Uniprot ID Q99985
Protein Name Semaphorin-3C
Gene Name SEMA3C
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.508
Function Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). .
GO - Molecular function
  • chemorepellent activity : IBA:GO_Central
  • semaphorin receptor binding : IBA:GO_Central
GO - Biological process
  • axon guidance : ISS:UniProtKB
  • blood vessel remodeling : IEA:Ensembl
  • cardiac endothelial to mesenchymal transition : IEA:Ensembl
  • cardiac right ventricle morphogenesis : IEA:Ensembl
  • dichotomous subdivision of terminal units involved in salivary gland branching : IEA:Ensembl
  • immune response : TAS:ProtInc
  • limb bud formation : IEA:Ensembl
  • negative chemotaxis : IBA:GO_Central
  • negative regulation of axon extension involved in axon guidance : IBA:GO_Central
  • neural crest cell migration : IBA:GO_Central
  • neural tube development : IEA:Ensembl
  • outflow tract septum morphogenesis : ISS:BHF-UCL
  • positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis : ISS:BHF-UCL
  • positive regulation of cell migration : IBA:GO_Central
  • post-embryonic development : IEA:Ensembl
  • pulmonary myocardium development : IEA:Ensembl
  • response to drug : TAS:ProtInc
  • semaphorin-plexin signaling pathway : IBA:GO_Central
  • somitogenesis : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.