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Q99715

Collagen alpha-1(XII) chain (Q99715)

Uniprot ID Q99715
Protein Name Collagen alpha-1(XII) chain
Gene Name COL12A1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.353
Function Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. .
GO - Molecular function
  • extracellular matrix structural constituent conferring tensile strength : NAS:UniProtKB
GO - Biological process
  • cell adhesion : IEA:UniProtKB-KW
  • collagen fibril organization : NAS:UniProtKB
  • endodermal cell differentiation : IEP:UniProtKB
  • growth plate cartilage chondrocyte morphogenesis : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.