| Signal peptide(a) |
N |
Secretome P(b) |
0.782 |
| Function |
Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum-and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto-and substrate-phosphorylations in a calcium-dependent manner. . |
| GO - Molecular function |
- calcium ion binding : IDA:UniProtKB
- calcium-dependent protein binding : IDA:UniProtKB
- kinase binding : ISS:UniProtKB
- microtubule binding : ISS:UniProtKB
- potassium channel regulator activity : TAS:ProtInc
- protein kinase inhibitor activity : IEA:UniProtKB-KW
- transporter activity : ISS:UniProtKB
|
| GO - Biological process |
- calcium ion regulated exocytosis : IEA:Ensembl
- cellular response to acidic pH : ISS:UniProtKB
- cytoplasmic microtubule organization : ISS:UniProtKB
- hyaluronan catabolic process : TAS:Reactome
- membrane docking : ISS:UniProtKB
- membrane fusion : ISS:UniProtKB
- membrane organization : ISS:UniProtKB
- microtubule bundle formation : ISS:UniProtKB
- negative regulation of calcineurin-NFAT signaling cascade : IDA:UniProtKB
- negative regulation of NF-kappaB transcription factor activity : IDA:UniProtKB
- negative regulation of phosphatase activity : IDA:UniProtKB
- negative regulation of protein autophosphorylation : ISS:UniProtKB
- negative regulation of protein import into nucleus : IDA:UniProtKB
- negative regulation of protein kinase activity : ISS:UniProtKB
- negative regulation of protein phosphorylation : ISS:UniProtKB
- negative regulation of protein ubiquitination : ISS:UniProtKB
- positive regulation of protein glycosylation : ISS:UniProtKB
- positive regulation of protein targeting to membrane : ISS:UniProtKB
- positive regulation of protein transport : ISS:UniProtKB
- positive regulation of sodium : IDA:UniProtKB
- potassium ion transport : TAS:ProtInc
- protein complex oligomerization : IEA:Ensembl
- protein export from nucleus : ISS:UniProtKB
- protein stabilization : ISS:UniProtKB
- regulation of intracellular pH : IDA:UniProtKB
- regulation of neuron death : IMP:UniProtKB
- small GTPase mediated signal transduction : TAS:ProtInc
|