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Q99627

COP9 signalosome complex subunit 8 (Q99627)

Uniprot ID Q99627
Protein Name COP9 signalosome complex subunit 8
Gene Name COPS8
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.743
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. .
GO - Molecular function
GO - Biological process
  • activation of NF-kappaB-inducing kinase activity : IMP:UniProtKB
  • COP9 signalosome assembly : IEA:InterPro
  • negative regulation of cell proliferation : IMP:UniProtKB
  • nucleotide-excision repair, DNA damage recognition : TAS:Reactome
  • post-translational protein modification : TAS:Reactome
  • protein deneddylation : IDA:UniProtKB
  • transcription-coupled nucleotide-excision repair : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.