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Q99542

Matrix metalloproteinase-19 (Q99542)

Uniprot ID Q99542
Protein Name Matrix metalloproteinase-19
Gene Name MMP19
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.376
Function Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. .
GO - Molecular function
  • metalloendopeptidase activity : EXP:Reactome
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • angiogenesis : IEA:UniProtKB-KW
  • cell differentiation : IEA:UniProtKB-KW
  • collagen catabolic process : IBA:GO_Central
  • extracellular matrix disassembly : TAS:Reactome
  • extracellular matrix organization : IBA:GO_Central
  • luteolysis : IEA:Ensembl
  • ovarian follicle development : IEA:Ensembl
  • ovulation from ovarian follicle : IEA:Ensembl
  • proteolysis : NAS:UniProtKB
  • response to cAMP : IEA:Ensembl
  • response to hormone : IEA:Ensembl
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.