Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
Q99439

Calponin-2 (Q99439)

Uniprot ID Q99439
Protein Name Calponin-2
Gene Name CNN2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.627
Function Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
GO - Molecular function
  • actin binding : TAS:ProtInc
  • cadherin binding : HDA:BHF-UCL
  • calmodulin binding : IEA:UniProtKB-KW
GO - Biological process
  • actomyosin structure organization : IEA:InterPro
  • cellular response to mechanical stimulus : IDA:MGI
  • cytoskeleton organization : TAS:ProtInc
  • interleukin-12-mediated signaling pathway : TAS:Reactome
  • neutrophil degranulation : TAS:Reactome
  • regulation of actin filament-based process : IDA:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.