Neurabin-2 (Q96SB3)

Uniprot ID	Q96SB3
Protein Name	Neurabin-2
Gene Name	PPP1R9B
Species	Homo sapiens (Human)

Signal peptide^(a)	N	Secretome P^(b)	0.259
Function	Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration. .
GO - Molecular function	actin filament binding : IBA:GO_Central D2 dopamine receptor binding : IEA:Ensembl ion channel binding : IEA:Ensembl kinase binding : IEA:Ensembl protein C-terminus binding : IEA:Ensembl protein kinase activity : IEA:Ensembl protein phosphatase 1 binding : NAS:UniProtKB protein phosphatase inhibitor activity : NAS:UniProtKB
GO - Biological process	actin filament depolymerization : IEA:Ensembl actin filament organization : IBA:GO_Central aging : IEA:Ensembl calcium-mediated signaling : IBA:GO_Central cell cycle arrest : TAS:UniProtKB cell migration : IMP:UniProtKB cellular response to epidermal growth factor stimulus : IEA:Ensembl cellular response to estradiol stimulus : IEA:Ensembl cellular response to morphine : ISS:UniProtKB cellular response to peptide : IEA:Ensembl cerebral cortex development : IEA:Ensembl dendrite development : IEA:Ensembl developmental process involved in reproduction : IEA:Ensembl filopodium assembly : IMP:UniProtKB hippocampus development : IEA:Ensembl learning : IEA:Ensembl male mating behavior : IEA:Ensembl modulation of chemical synaptic transmission : IEA:InterPro negative regulation of cell growth : IDA:UniProtKB neuron projection development : IBA:GO_Central positive regulation of protein localization to actin cortical patch : IEA:Ensembl positive regulation of protein localization to plasma membrane : IEA:Ensembl protein localization to actin cytoskeleton : IEA:Ensembl protein localization to cell periphery : IEA:Ensembl regulation of cell growth by extracellular stimulus : TAS:UniProtKB regulation of cell population proliferation : NAS:UniProtKB regulation of exit from mitosis : NAS:UniProtKB regulation of opioid receptor signaling pathway : ISS:UniProtKB regulation of protein phosphorylation : IEA:Ensembl reproductive system development : IEA:Ensembl response to amphetamine : IEA:Ensembl response to clozapine : IEA:Ensembl response to immobilization stress : IEA:Ensembl response to kainic acid : IEA:Ensembl response to L-phenylalanine derivative : IEA:Ensembl response to nicotine : IEA:Ensembl response to prostaglandin E : IEA:Ensembl response to steroid hormone : IEA:Ensembl RNA splicing : NAS:UniProtKB

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}