Alsin (Q96Q42)

Uniprot ID Q96Q42
Protein Name Alsin
Gene Name ALS2
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.51
Function May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). .
GO - Molecular function
  • GTPase activator activity : IDA:MGI
  • identical protein binding : IDA:MGI
  • protein homodimerization activity : IPI:UniProtKB
  • protein serine/threonine kinase activator activity : IDA:UniProtKB
  • Rab GTPase binding : IDA:UniProtKB
  • Rab guanyl-nucleotide exchange factor activity : IDA:UniProtKB
  • Rac GTPase binding : IDA:MGI
  • Rac guanyl-nucleotide exchange factor activity : IDA:UniProtKB
GO - Biological process
  • axonogenesis : IEA:Ensembl
  • behavioral fear response : IEA:Ensembl
  • cell death : IEA:Ensembl
  • endosomal transport : IEA:Ensembl
  • endosome organization : IGI:MGI
  • in utero embryonic development : IEA:Ensembl
  • locomotory behavior : IEA:Ensembl
  • lysosomal transport : IDA:MGI
  • neuromuscular junction development : IEA:Ensembl
  • neuron projection morphogenesis : IDA:UniProtKB
  • positive regulation of GTPase activity : IDA:UniProtKB
  • positive regulation of protein kinase activity : IDA:UniProtKB
  • positive regulation of Rac protein signal transduction : IC:UniProtKB
  • protein homooligomerization : IDA:MGI
  • protein localization : IEA:Ensembl
  • Rac protein signal transduction : IEA:Ensembl
  • receptor recycling : IEA:Ensembl
  • regulation of endosome size : IEP:UniProtKB
  • response to oxidative stress : IEA:Ensembl
  • synaptic transmission, glutamatergic : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.