Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
Q96FE5

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Q96FE5)

Uniprot ID Q96FE5
Protein Name Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Gene Name LINGO1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.377
Function Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). .
GO - Molecular function
  • epidermal growth factor receptor binding : IBA:GO_Central
GO - Biological process
  • negative regulation of axonogenesis : TAS:Reactome
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.