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Q96B86

Repulsive guidance molecule A (Q96B86)

Uniprot ID Q96B86
Protein Name Repulsive guidance molecule A
Gene Name RGMA
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.337
Function Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. .
GO - Molecular function
  • coreceptor activity : IBA:GO_Central
  • transferrin receptor binding : IPI:BHF-UCL
GO - Biological process
  • BMP signaling pathway : IBA:GO_Central
  • negative regulation of axon regeneration : IEA:InterPro
  • positive regulation of transcription by RNA polymerase II : IDA:BHF-UCL
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.