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Q969V6

Myocardin-related transcription factor A (Q969V6)

Uniprot ID Q969V6
Protein Name Myocardin-related transcription factor A
Gene Name MRTFA
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.219
Function Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. .
GO - Molecular function
  • actin binding : IDA:UniProtKB
  • actin monomer binding : ISS:UniProtKB
  • leucine zipper domain binding : IPI:BHF-UCL
  • transcription coactivator activity : ISS:UniProtKB
GO - Biological process
  • actin cytoskeleton organization : ISS:UniProtKB
  • positive regulation of transcription by RNA polymerase II : IDA:BHF-UCL
  • positive regulation of transcription via serum response element binding : IDA:UniProtKB
  • smooth muscle cell differentiation : IMP:BHF-UCL
  • wound healing, spreading of cells : IDA:CACAO
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.