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Q93063

Exostosin-2 (Q93063)

Uniprot ID Q93063
Protein Name Exostosin-2
Gene Name EXT2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.62
Function Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). .
GO - Molecular function
  • glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity : IEA:UniProtKB-EC
  • glucuronosyltransferase activity : IDA:BHF-UCL
  • heparan sulfate N-acetylglucosaminyltransferase activity : NAS:BHF-UCL
  • metal ion binding : IEA:UniProtKB-KW
  • N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity : NAS:BHF-UCL
  • protein heterodimerization activity : IPI:BHF-UCL
  • transferase activity, transferring glycosyl groups : IDA:BHF-UCL
GO - Biological process
  • cell differentiation : IEA:Ensembl
  • cellular polysaccharide biosynthetic process : IDA:BHF-UCL
  • glycosaminoglycan biosynthetic process : IDA:BHF-UCL
  • heparan sulfate proteoglycan biosynthetic process : IMP:BHF-UCL
  • heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process : IMP:BHF-UCL
  • mesoderm formation : IEA:Ensembl
  • ossification : IMP:BHF-UCL
  • protein glycosylation : IEA:UniProtKB-UniPathway
  • signal transduction : TAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.