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Q92859

Neogenin (Q92859)

Uniprot ID Q92859
Protein Name Neogenin
Gene Name NEO1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.197
Function Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. .
GO - Molecular function
  • co-receptor binding : IPI:BHF-UCL
  • signaling receptor activity : IEA:InterPro
GO - Biological process
  • axon guidance : IEA:InterPro
  • cell adhesion : NAS:ProtInc
  • iron ion homeostasis : IGI:MGI
  • positive regulation of BMP signaling pathway : IEA:InterPro
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.